Journal of Liver Cancer

Review Article

Diagnosis of hepatocellular carcinoma using Sonazoid: a comprehensive review: Woo Kyoung Jeong; J Liver Cancer. 2023;23(2):272-283. Published online September 19, 2023; DOI: https://doi.org/10.17998/jlc.2023.08.25

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Sonazoid contrast-enhanced ultrasonography (CEUS) is a promising technique for the detection and diagnosis of focal liver lesions, particularly hepatocellular carcinoma (HCC). Recently, a collaborative effort between the Korean Society of Radiology and Korean Society of Abdominal Radiology resulted in the publication of guidelines for diagnosing HCC using Sonazoid CEUS. These guidelines propose specific criteria for identifying HCC based on the imaging characteristics observed during Sonazoid CEUS. The suggested diagnostic criteria include nonrim arterial phase hyperenhancement, and the presence of late and mild washout, or Kupffer phase washout under the premise that the early or marked washout should not occur during the portal venous phase. These criteria aim to improve the accuracy of HCC diagnosis using Sonazoid CEUS. This review offers a comprehensive overview of Sonazoid CEUS in the context of HCC diagnosis. It covers the fundamental principles of Sonazoid CEUS and its clinical applications, and introduces the recently published guidelines. By providing a summary of this emerging technique, this review contributes to a better understanding of the potential role of Sonazoid CEUS for diagnosing HCC.

Citations

Citations to this article as recorded by

Diagnostic Test Accuracy of Contrast‐Enhanced Ultrasound With Sonazoid for Assessment of Focal Liver Lesions: A Systematic Review and Meta‐Analysis
Yongqing Tang, Shun‐ichi Sasaki, Joshua Hawley, Aurélie Peillon, Anders Sjöström, Adolfo Fuentes‐Alburo, Francois Tranquart
Journal of Clinical Ultrasound.2025; 53(3): 510. CrossRef
The Clinical Utility of Liver-Specific Ultrasound Contrast Agents During Hepatocellular Carcinoma Imaging
Joshua Hawley, Yongqing Tang, Anders Sjöström, Adolfo Fuentes-Alburo, François Tranquart
Ultrasound in Medicine & Biology.2025; 51(3): 415. CrossRef
Echo contrast medium: How the use of contrast echocardiography (ultrasound contrast agents) can improve patient care
Kevan English
World Journal of Methodology.2025;[Epub] CrossRef
Differentiation of AFP-negative hepatocellular carcinoma from other intrahepatic malignant lesions by a noninvasive predictive model based on Sonazoid contrast-enhanced ultrasound
Qian Zhang, Zhilong Liu, Ruining Wang, Lele Song, Wenwen Fan, Ping Liang, Liping Liu
Frontiers in Oncology.2025;[Epub] CrossRef
HCC in the Era of Emerging MASH: The Role of Ultrasound in Surveillance and New Sonographic Features in Diagnosis
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Cancers.2025; 17(24): 4037. CrossRef
The Diagnostic Impact of Contrast-Enhanced Computed Tomography (CECT) in Evaluating Lymph Node Involvement in Colorectal Cancer: A Comprehensive Review
Akash Inamdar, Raju K Shinde
Cureus.2024;[Epub] CrossRef
Sonazoid contrast-enhanced ultrasonography for the diagnosis of hepatocellular carcinoma: strengths and shortcomings
Sung Won Lee, Min Kyu Kang, Xiang Zhang
Journal of Liver Cancer.2023; 23(2): 238. CrossRef

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