Journal of Liver Cancer

Original Article

Recent update of proton beam therapy for hepatocellular carcinoma: a systematic review and meta-analysis: Sun Hyun Bae, Won Il Jang, Hanna Rahbek Mortensen, Britta Weber, Mi Sook Kim, Morten Høyer; J Liver Cancer. 2024;24(2):286-302. Published online July 4, 2024; DOI: https://doi.org/10.17998/jlc.2024.06.26

11,234 Views
234 Downloads
10 Citations

Backgrounds/Aims
Although access to proton beam therapy (PBT) is limited worldwide, its use for the treatment of hepatocellular carcinoma (HCC) is gradually increasing with the expansion of new facilities. Therefore, we conducted a systematic review and metaanalysis to investigate the updated evidence of PBT for HCC.
Methods
The MEDLINE, EMBASE, Cochrane Library, and Web of Science databases were systematically searched for studies that enrolled patients with liver-confined HCC that were treated with PBT for a cure up to February 2024.
Results
A total of 1,858 HCC patients receiving PBT from 22 studies between 2004 and 2023 were selected for this meta-analysis. The median proportion of Child-Pugh class A was 86% (range, 41-100), and the median tumor size was 3.6 cm (range, 1.2-9.0). The median total dose ranged from 55 GyE to 76 GyE (median, 69). The pooled rates of 3- and 5-year local progression-free survival after PBT were 88% (95% confidence interval [CI], 85-91) and 86% (95% CI, 82-90), respectively. The pooled 3- and 5-year overall rates were 60% (95% CI, 54-66) and 46% (95% CI, 38-54), respectively. The pooled rates of grade 3 hepatic toxicity, classic radiationinduced liver disease (RILD), and non-classic RILD were 1%, 2%, and 1%, respectively.
Conclusions
The current study supports PBT for HCC and demonstrates favorable long-term survival and low hepatic toxicities compared with other published studies on other radiotherapy modalities. However, further studies are needed to identify the subgroups that will benefit from PBT.

Citations

Citations to this article as recorded by

Tailored proton beam therapy for hepatocellular carcinoma: Addressing unmet needs through a multidisciplinary approach
Jeong Ha Lee, Nalee Kim, Jeong Il Yu, Hee Chul Park, Sungkoo Cho, Byeong Geun Song, Myung Ji Goh, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Joon Hyeok Lee, Yong-Han Paik, Moon Seok Choi, Minsuk Kwon, Jung Yong Hong, Gyu-Seong Choi, Woo Kyoung Jeong, M
European Journal of Cancer.2026; 237: 116593. CrossRef
Recent advancements in radiotherapy for hepatocellular carcinoma
L.L. Chan, K.S.H. Chok, A.Y.H. Ip, D.M.C. Poon, S.L. Chan
ESMO Gastrointestinal Oncology.2026; 11: 100308. CrossRef
Deep learning-based dose prediction in proton beam therapy for hepatocellular carcinoma: comparison of network architectures and loss functions
Shuta Ogawa, Noriyuki Kadoya, Takahiro Kato, Ryohei Kato, Ryota Tozuka, Yuki Narita, Sho Oyama, Masao Murakami, Keiichi Jingu
Journal of Radiation Research.2026; 67(3): 369. CrossRef
A concise review of updated global guidelines for the management of hepatocellular carcinoma: 2017-2024
Hyunjae Shin, Su Jong Yu
Journal of Liver Cancer.2025; 25(1): 19. CrossRef
Radiotherapy for Locally Advanced Pancreatic Cancer in the Modern Era: A Systematic Review and Meta-Analysis
Sun Hyun Bae, Won Il Jang, Jeong Il Yu, Hee Chul Park, Ji Eun Moon, Karin Haustermans, Marta Scorsetti, Morten Høyer, Mi Sook Kim
Cancers.2025; 17(18): 2959. CrossRef
CAPG Regulates Doxorubicin Resistance in Hepatocellular Carcinoma Cells via TGFB1/Smad/Nrf2 Signalling Pathway
Yue Shang, Jun Zhang, Tingting Liu
Journal of Cellular and Molecular Medicine.2025;[Epub] CrossRef
Navigating the Therapeutic Pathway and Optimal First-Line Systemic Therapy for Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors
Hyun Phil Shin, Moonhyung Lee
Medicina.2025; 61(12): 2164. CrossRef
Radiotherapy Combined with Immune Checkpoint Inhibitor on Murine Fibrosarcoma and a Narrative Review of Clinical Studies
Wonwoo Kim, Hyunkyung Kim, Won Il Jang, Mi Sook Kim, Sun Hyun Bae
Current Issues in Molecular Biology.2025; 48(1): 20. CrossRef
Radiotherapy for Liver-Confined Hepatocellular Carcinoma in Elderly Patients with Comorbidity
Sun Hyun Bae, Young Seok Kim, Sang Gyune Kim, Jeong-Ju Yoo, Jae Myeong Lee, Sanghyeok Lim, Jae Hong Jung, Chan Kyu Kim
Cancers.2025; 18(1): 91. CrossRef
Proton Radiotherapy Alone versus Combined with Immunotherapies or Tyrosine Kinase Inhibitors for Barcelona Clinic Liver Cancer Stage B or C Hepatocellular Carcinoma
Rodney Cheng-En Hsieh, Willy Po-Yuan Chen, Jin-Chiao Lee, Chia-Hsin Lin, Yu-Chen Chang, Chao-Wei Lee, Kun-Ming Chan, Hao-Chien Hung, Tony Kuo, Shen-Yen Lin, Tse-Ching Chen, Ting-Jung Wu, Chung-Wei Su, Hong-Shiue Chou, Chih-Hsien Cheng, Yi-Chung Hsieh, Che
Liver Cancer.2025; : 1. CrossRef

First
Prev
Page of 1
Next
Last

Search