Curative treatment of hepatocellular carcinoma (HCC) with portal vein invasion is difficult to achieve, and the prognosis is dismal. Combining external beam radiotherapy (EBRT) with hepatic arterial infusion chemotherapy (HAIC) has shown favorable local therapeutic effects for patients with HCC exhibiting portal vein invasion. Stereotactic body radiotherapy (SBRT) is a recently developed EBRT modality that shows excellent tumor control. The combination of SBRT and HAIC for HCC with portal vein invasion has not been well-studied. We report a patient with HCC and portal vein invasion who achieved 15 months of survival with complete response status after combination SBRT and HAIC. The patient later experienced grade 3 biliary stricture and died of liver abscesses of unknown etiologies that subsequently appeared.
Sorafenib is the standard treatment for advanced hepatocellular carcinoma according to
the Barcelona Clinic Liver Cancer staging system. However, because of its unsatisfactory
efficacy, adverse effects, and high cost, the use of sorafenib is limited, and other treatment
modalities are required. Recent studies reported that treatment modalities other than
sorafenib, such as hepatic arterial infusion chemotherapy and transarterial radioembolization,
showed comparable or better response rates and survival rates than sorafenib. In this review,
treatment modalities that could be used as alternatives to sorafenib will be discussed. (J Liver
Cancer 2016;16:1-6)
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Phase I Radiation Dose-Escalation Study to Investigate the Dose-Limiting Toxicity of Concurrent Intra-Arterial Chemotherapy for Unresectable Hepatocellular Carcinoma Yeona Cho, Jun Won Kim, Ja Kyung Kim, Kwan Sik Lee, Jung Il Lee, Hyun Woong Lee, Kwang-Hun Lee, Seung-Moon Joo, Jin Hong Lim, Ik Jae Lee Cancers.2020; 12(6): 1612. CrossRef
Myung Eun Song, Sangheun Lee, Mi Na Kim, Dong-Jun Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Chae Yoon Chon, Kwang-Hyub Han, Jinsil Seong, Do Young Kim
Journal of the Korean Liver Cancer Study Group. 2013;13(2):152-157. Published online September 30, 2013
A 63-year-old man patient was referred for treatment of infiltrative hepatocellular carcinoma with hilar invasion after transarterial chemoembolization. Serum alkaline phosphatase and bilirubin were elevated, liver dynamic CT showed infiltrative type mass in left hepatic lobe and right hepatic dome with hilar invasion and left intrahepatic duct dilatation. Also CT showed obliteration of left portal vein and metastasis of lymph node around common bile duct. He was diagnosed as hepatocellular carcinoma (UICC stage IV-A, BCLC stage C). With the percutaneous transhepatic biliary drainage and the concurrent chemoradiation therapy and the 4th cycle of hepatic arterial infusion chemotherapy for infiltrative mass, viable tumor was decreased in resectable size at eight months from initial diagnosis.
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Surgery, percutaneous ablation and liver
transplantation are the only curative treatment modality for HCC. However, a majority of patients have unresectable disease at
diagnosis. Despite radical treatment, high risk of tumor recurrence is the most common problem. Therefore, there is a need for
effective treatment options for patients with advanced or recurrent HCC. For patients with advanced stage of HCC according to
the Barcelona Clinic Liver Cancer staging system, the multikinase inhibitor sorafenib is the current standard of care. However,
hepatic arterial infusion chemotherapy (HAIC) have been applied to advanced stage HCC with a view to improve the therapeutic
indexes in Asia. HAIC provides direct drug delivery into tumor bed and a greater first‐pass effect; also systemic side effects can
be potentially minimized. However, the sample size of researches on HAIC was small and large randomized trials are still
lacking. In this article, we describe the treatment efficacy of HAIC for advanced stage HCC and discuss future therapeutic
possibilities.
Hepatocellular carcinoma (HCC) is the third most common malignancy in Korea where chronic hepatitis B virus is prevalent.
More than 60-70% of HCC cases are diagnosed at an advanced stage that are not eligible for curative therapy such as surgical
resection, liver transplantation, radiofrequency ablation, and percutaneous ethanol injection. According to Barcellona Clinic
Liver Cancer (BCLC) staging and treatment, standard treatment of advanced HCC is sorafenib. And there are some reports that
hepatic arterial infusion chemotherapy (HAIC) could be a beneficial therapeutic option for patients with advanced HCC. We
report a case of advanced HCC with portal vein thrombosis that received liver transplantation after combination treatment of
HAIC and sorafenib.
Hepatic arterial infusion chemotherapy (HAIC) is performed in patients with advanced hepatocellular carcinoma (HCC) in
which locoregional therapeutic methods such as transarterial chemoembolization (TACE), percutaneous ethanol injection (PEI)
or radiofrequency ablation (RFA) could not be the best choice. Sorafenib, the only approved systemic chemotherapeutic agent
for HCC, improves survival rate, but is associated with a low tumor response rate. Thus combining these therapeutic modalities to
treat HCC in advanced stage may help downstaging and leading to better treatment results without taking risk for hepatic failure.
Here we report a case treated to a complete remission by combining HAIC, PEI and sorafenib.
Hepatocellular carcinoma (HCC) is the third most common malignancy in Korea. Despite recent advances in the area of
HCC, a considerable number of HCC patients require non-surgical treatments and systemic therapies because of poor liver
function or intermediate to advanced cancer stages at the time of diagnosis. Unfortunately, chemotherapy for advanced HCC
has limited response rates and provides a marginal survival benefit. Several studies have supported potential advantages of
hepatic arterial infusion chemotherapy (HAIC), designed to improve chemotherapy benefits by increasing the amount of
chemotherapy delivered to the site of the tumor and to minimizes the side-effects of the chemotherapy. However, there hasn’t
been any report showing different responses between systemic chemotherapy and HAIC for the same patient. Herein, we
report a case of HCC showing progressive disease in systemic chemotherapy, but partial response in HAIC with the same
regimen for the same patient with portal vein thrombosis. This case implies HAIC might be alternative option for HCC
patient showing ineffective response to systemic chemotherapy, even with the same regimen.